New Treatment Shows Promising Results in Treating Major Depressive Symptoms

New Treatment Shows Promising Results in Treating Major Depressive Symptoms

A recent study conducted by researchers at UCLA Health has unveiled a breakthrough in the treatment of major depressive symptoms. The study reveals the effectiveness of a novel treatment called repetitive transcranial magnetic stimulation (rTMS), even in patients who have failed multiple courses of antidepressant medication. Notably, the treatment demonstrates rapid relief, with symptoms starting to alleviate as soon as one week.

The research, carried out by UCLA’s Neuromodulation Division, examined the outcomes of hundreds of patients who underwent rTMS therapy at UCLA Health between 2009 and 2022. rTMS therapy employs magnetic fields to rewire the brain’s circuitry effectively. The study, published in the journal Psychiatry Research, found that more than half of the patients (54%) exhibited a clinical response, with a significant improvement of at least 50% in mood symptoms measured on multiple depression rating scales.

Lead author Dr. Michael K. Leuchter, a senior psychiatry resident at the Semel Institute, explained UCLA’s unique approach to rTMS treatment. Patients receive individualized care, seeing a psychiatrist at each treatment session, and their symptoms are measured weekly using multiple rating scales that adhere to a measurement-based care approach. This enhanced approach has allowed the researchers to assess treatment benefits more accurately than prior studies that used fewer measurement scales.

What makes these findings particularly exciting is that patients reported feeling better within a week of starting treatment, even though the treatment itself lasts for several weeks. Standard rTMS treatment entails 20-30-minute sessions, five days a week, for six to eight weeks. Approved by the U.S. Food and Drug Administration in 2008, rTMS has been shown to be effective for treating medication-resistant major depressive disorder.

One interesting discovery from the study is that the effectiveness of rTMS can vary among patients. The researchers found that using multiple depression rating scales, as opposed to just one, allows for better detection and characterization of treatment effectiveness. Patients who demonstrated early improvements within the first five or ten treatments were more likely to respond positively throughout the entire course of treatment. This finding suggests that doctors could modify their clinical approach based on early responses to tailor treatment for each patient.

As the field of neuroscience continues to advance, the development of innovative treatments like rTMS offers hope and promise for individuals battling major depressive symptoms. The results of this study open new possibilities for achieving rapid relief and improving the lives of those affected by depression.


What is repetitive transcranial magnetic stimulation (rTMS)?
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive treatment that uses magnetic fields to stimulate specific brain circuits involved in regulating mood. It is approved by the U.S. Food and Drug Administration as a treatment for medication-resistant major depressive disorder.

How does rTMS work?
rTMS therapy involves delivering magnetic pulses to targeted areas of the brain. These pulses stimulate nerve cells and help modulate brain circuitry associated with mood regulation.

What are the benefits of rTMS in treating major depressive symptoms?
The study conducted by UCLA Health researchers suggests that rTMS is an effective treatment option, even for patients who have not responded well to traditional antidepressant medications. It offers rapid relief, with symptoms starting to improve as early as one week into treatment.

How long does rTMS treatment typically last?
Standard rTMS treatment consists of 20-30-minute sessions, five days a week, for a duration of six to eight weeks. The length of treatment may be adjusted based on individual patient needs and progress.

What are the potential factors contributing to the variability in rTMS effectiveness?
According to the UCLA study, the use of multiple depression rating scales can help better assess and characterize the effectiveness of rTMS treatment. Early improvements within the first few treatments have also been found to be predictive of long-term response, allowing doctors to modify treatment approaches if necessary.

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