Research published in JAMA Network Open has shed light on the relationship between statin usage, cholesterol levels, and breast cancer mortality. This study aimed to determine the impact of statin use and serum cholesterol levels on the survival of women with breast cancer.
Background: Breast cancer is the most common cancer among women worldwide, with post-metastasis survival rates being particularly poor. Previous research has suggested that statin usage may improve survival rates in breast cancer patients. However, most studies did not consider baseline cholesterol levels or changes caused by statin use, resulting in inconsistent findings.
About the study: In this population-based retrospective cohort study, Finnish women with invasive breast cancer diagnosed between 1995 and 2013 were included. The study analyzed data on hormone receptors, cholesterol levels, and breast cancer treatments. The effect of statin use and cholesterol levels on breast cancer mortality was assessed.
Results: The study included 13,378 breast cancer patients with a median age of 62 years. During the follow-up period, 16% of individuals died, with 7% of those deaths being attributed to breast cancer. The analysis revealed that statin use before breast cancer diagnosis was associated with an increased risk of breast cancer mortality compared to non-use. However, post-diagnostic statin use was linked to a reduced risk of breast cancer mortality. The risk reduction was greater with higher intensity statin use and among patients with reduced cholesterol levels.
Interpretation: The findings suggest that post-diagnostic statin use may lower breast cancer mortality, potentially through mechanisms other than cholesterol reduction. However, the study also found that statin use among females with metastatic tumors increased the risk of mortality. These results indicate that statins might be beneficial primarily for patients with early-stage breast cancer.
Q: What is the main finding of this study?
A: The study found that post-diagnostic statin use was associated with a decreased risk of breast cancer mortality in women, mediated by serological cholesterol levels.
Q: What was the significance of cholesterol levels in this study?
A: Cholesterol is a precursor for estrogen production, which raises the risk of breast cancer. The study suggests that lowering cholesterol levels with statins could benefit breast cancer patients.
Q: Did statin use have the same effect on all breast cancer patients?
A: No, the study observed that statin use was associated with increased mortality among patients with metastatic tumors but reduced mortality among patients with early-stage breast cancers.
Q: What are the implications of this research?
A: This study highlights the potential benefits of statin use in breast cancer treatment, particularly for patients with early-stage tumors. It suggests that additional research is needed to understand the mechanisms underlying these findings.
(Source: JAMA Network Open)