Pediatric patients with moderate-to-severe or recurrent Clostridioides difficile infection (CDI) may benefit from fecal microbiota transplantation (FMT), according to a clinical report published in Pediatrics. FMT has been widely recognized as an effective treatment for CDI in adults, but limited data is available for its application in children.
Considering the lack of prospective clinical trials in pediatric patients, Maria Oliva-Hemker, M.D., and her colleagues from Johns Hopkins University School of Medicine comprehensively reviewed the use of FMT in children. Their objective was to provide guidance to families seeking FMT treatment for their children with CDI.
While no prospective clinical trials evaluating FMT in children have been conducted, studies have shown that FMT is beneficial for pediatric patients with moderate-to-severe or recurrent CDI. However, it is important to note that FMT is not recommended for the treatment of other medical conditions in children.
To ensure safety and efficacy, it is strongly advised that FMT should not be performed at home. Instead, the procedure should be conducted in centers with relevant expertise and experience. Regulatory standards for fecal preparations used in FMT are currently lacking, and the long-term effects of FMT in pediatric patients remain unknown.
The authors of the clinical report also emphasize the need for pediatric populations to be included in clinical trials for microbial therapeutic products. While the prospect of commercial microbiota therapeutics is promising, it is crucial to address the unique challenges they may pose for children.
As the field of antimicrobial therapies continues to advance rapidly, it is anticipated that new commercial products for the treatment of CDI will become available. However, further research is needed to evaluate their efficacy and safety specifically in pediatric patients.
Q: Has FMT been proven effective for CDI in children?
A: While there are no prospective clinical trials for FMT in children with CDI, studies have shown that FMT is beneficial for pediatric patients with moderate-to-severe or recurrent CDI.
Q: Can FMT be performed at home for children?
A: No, for safety reasons, at-home FMT should not be performed in children. It is recommended to have the procedure conducted in centers with experience in FMT.
Q: Are there regulatory standards for fecal preparations used in FMT?
A: Currently, there are lacking regulatory standards for fecal preparations used in FMT.
Q: What are the long-term effects of FMT in pediatric patients?
A: The long-term effects of FMT in pediatric patients are currently unknown and require further investigation.
– Fecal Microbiota Transplantation: Information for the Pediatrician
– HealthDay, “Fecal Microbiota Transplantation for Pediatric Patients with Clostridioides Difficile Infection” (2023)